Knowledge‐Based Conceptual Synthesis of Industrial‐Scale Downstream Processes for Biochemical Products

A generic, knowledge‐based guideline assisting downstream process synthesis for biochemical products is presented. It offers process designers a structured process design methodology supporting them in capturing potentially relevant information, which might be beyond their expertise. The guideline is based on heuristic knowledge which was collected, structured in a generic way, and clearly represented. The generation of alternative downstream routes as starting points for experiments, simulation, and cost calculation is hereby accelerated. The application of the guideline is demonstrated on the example of penicillin V downstream processing from fermentation broth.     

A novel set-up and a CFD approach to study the biofilm dynamics as a function of local flow conditions encountered in fresh-cut food processing equipments

The hydrodynamic conditions as well as design and surface properties within fresh-cut food processing equipment create a complex environment for biofilms. A new experimental approach was thus proposed to identify those physical parameters impacting biofilm development in such conditions. A set-up comprising original mock-ups mimicking generic features of washing tanks (e.g. welds, folds, flat surfaces, air/liquid/wall interface) was designed. The flow pattern therein was characterized using two computational fluid dynamic calculation approaches. Full trials were run for 48 h at 10 °C with a Pseudomonas fluorescens strain to identify the preferential biofilm formation areas. As in current industrial systems, the pilot rig had recirculation areas and low wall shear stress rates (τ_w < 0.1 Pa) in corners and angles. These were identified as critical areas with Surface Microbial Loads (SML) over 5 Log₁₀/cm². However, τ_w alone failed to explain why SML in areas under unidirectional flow was higher than in the mock-ups. Lastly, air/liquid/wall interface conditions were more critical than immersed surfaces. This study validated the possibility of using CFD methods to understand the way in which flow pattern influences biofilm formation. The methodology proposed would be helpful in quantifying equipment components criticality based on biofilm growth parameters.     

Computing the regularization of a linear differential–algebraic system

We study the regularization problem for linear differential–algebraic systems. As an improvement of former results we show that any system can be regularized by a combination of state-space and input-space transformations, behavioral equivalence transformations and a reorganization of variables. The additional state feedback which is needed in earlier publications is shown to be superfluous. We provide an algorithmic procedure for the construction of the regularization and discuss computational aspects.     

Adaptive–interpolative binarization with stroke preservation for restoration of faint characters in degraded documents

A novel technique for binarization with stroke preservation of faint characters in degraded documents is proposed. It works in a multi-scale framework with an adaptive–interpolative thresholding technique. Instead of computing a global threshold value, it computes the local threshold values for a small set of grid points by observing the intensity pattern of the pixels lying in the concerned grid cells. Estimated thresholds are used, in turn, to compute the threshold values of all the remaining pixels using a fast-yet-efficient interpolation procedure. To handle noises in degraded images, this grid-based adaptive thresholding is applied in successively reducing scales to obtain the near-optimal binarization as a set of connected components. After a post-processing meant for stroke preservation with these connected components, we get the final output. Exhaustive experimentation and comparison with other existing methods have been successfully carried out with benchmark datasets and also with our own datasets.     

The driver,the road,the rules … and the rest? A systems-based approach to young driver road safety

The persistent overrepresentation of young drivers in road crashes is universally recognised. A multitude of factors influencing their behaviour and safety have been identified through methods including crash analyses, simulated and naturalistic driving studies, and self-report measures. Across the globe numerous, diverse, countermeasures have been implemented; the design of the vast majority of these has been informed by a driver-centric approach. An alternative approach gaining popularity in transport safety is the systems approach which considers not only the characteristics of the individual, but also the decisions and actions of other actors within the road transport system, along with the interactions amongst them. This paper argues that for substantial improvements to be made in young driver road safety, what has been learnt from driver-centric research needs to be integrated into a systems approach, thus providing a holistic appraisal of the young driver road safety problem. Only then will more effective opportunities and avenues for intervention be realised.     

Examining the Suitability of the Reaction Engineering Approach (REA) to Modeling Local Evaporation/Condensation Rates of Materials with Various Thicknesses

The reaction engineering approach (REA) is examined here to investigate its suitability as the local evaporation rate to be used in multiphase drying. For this purpose, REA is first implemented to model the convective drying of materials with various thicknesses. The relative activation energy, as the fingerprint of REA, generated from one size of a material is used to model the convective drying of the same material with different thicknesses. Because the results indicate that REA parameters can model the drying of materials with various thicknesses, REA can be scaled down to describe the local evaporation rate (at the microscale as affected by local composition and temperature). The relative activation energy is used to describe the global drying rate in modeling the local evaporation rate. REA is combined with a system of equations of conservation of heat and mass transfer in order to yield the spatial reaction engineering approach (S-REA) as a nonequilibrium multiphase drying model. By using S-REA, the spatial profiles of moisture content, concentration of water vapor, temperature, and local evaporation rate can be generated, which can assist in comprehending the transport phenomena.     

浅析门式钢架结构在池窑拉丝厂中的应用

介绍了门式钢架结构的力学原理和结构组成,分析了门式钢架结构的特点、优势及建筑布置要点,结合具体工程案例重点对门式钢架与网架结构经济性能方案进行了比较和探究,并展望门式钢架结构的发展趋势.     

焦炉气甲烷化过程模拟计算顺序的确定

序贯模块法广泛应用于化工过程流程模拟。对于具有回路的化工过程,其计算顺序的确定是很重要的问题。本文针对有回路的焦炉气甲烷化流程进行了分析,确定了其模拟计算时的计算顺序,对焦炉气甲烷化流程的研究具有很好的参考价值。     

Zum Tragverhalten der selbstregulierenden interaktiven Membrangründung

On the load bearing behavior of the self‐regulating interactive membrane foundation system The paper reports on a new foundation system, the self‐regulating membrane foundation, for embankments on deep soft soil deposits, such as stockpiles or infrastructure embankments. The load bearing behavior of the system was analyzed by means of centrifuge model tests and comprehensive numerical simulations, such as global sensitivity analyses and parametric studies. The results of those analyses and the derived design approach are presented in the paper. The paper concludes with a validation of the design approach, by comparison with results of the numerical simulation.